Study Med Gas Res 2019

The National Brain Injury Rescue and Rehabilitation Study - a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms

Mozayeni B, Duncan W, Zant E, Love T, Beckman R, Stoller K — Med Gas Res, 2019

View Original on PubMed PMID 30950414

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a multicenter observational study testing the safety and feasibility of HBOT (40 to 82 sessions at 1.5 ATA for one hour each) in 32 patients with chronic post-concussive symptoms from mild traumatic brain injury, measuring neurocognitive outcomes.

What They Found

Subjects showed improvement in 21 of 25 neurocognitive test measures. Objective cognitive test components improved in 13 of 17 measures. Earlier treatment after injury, younger age, military status, and more HBOT sessions were all associated with better outcomes. No adverse events were reported.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This was a small, non-randomised observational study with no control group; the absence of a sham condition means placebo effects cannot be ruled out.

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Study Details

Study Type	Study
Category	Neurological
Source	Pubmed
PubMed ID	30950414
Year Published	2019
Journal	Med Gas Res
MeSH Terms	Adult; Brain Injuries, Traumatic; Female; Humans; Hyperbaric Oxygenation; Male; Mental Status and Dementia Tests; Military Personnel; Outcome Assessment, Health Care; Post-Concussion Syndrome; Rehabilitation Research; Severity of Illness Index; Stress Disorders, Post-Traumatic; Young Adult

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology