Study Medicine (Baltimore) 2021

The occurrence of delayed neuropsychologic sequelae in acute carbon monoxide poisoning patients after treatment with hyperbaric or normobaric oxygen therapy

Yang C, Chuang Y, Chen P, Tao P, Tung T, Chien C — Medicine (Baltimore), 2021

View Original on PubMed PMID 33466193

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a nationwide population-based cohort study using Taiwan's National Health Insurance Research Database to compare hyperbaric oxygen and normobaric oxygen therapies for reducing delayed neuropsychologic sequelae in carbon monoxide poisoning patients.

What They Found

Patients treated with hyperbaric oxygen (HBO) therapy had a 1.87-fold higher risk of developing delayed neuropsychologic sequelae (DNS) compared to those receiving normobaric oxygen (NBO) therapy (P < .001). The severity of carbon monoxide poisoning and pre-existing comorbidities also significantly influenced the risk of developing DNS.

Canadian Relevance

This study was conducted using Taiwan's National Health Insurance Research Database and has no direct Canadian connection.

Study Limitations

A limitation of this study is its reliance on administrative database records, which may not capture all clinical details or confounding factors.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

Was this summary helpful?

Study Details

Study Type	Study
Category	Neurological
Source	Pubmed
PubMed ID	33466193
Year Published	2021
Journal	Medicine (Baltimore)
MeSH Terms	Adult; Carbon Monoxide Poisoning; Cohort Studies; Disease Progression; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Neuropsychological Tests; Oxygen Inhalation Therapy; Quality of Health Care

Related Research

PLoS ONE | 2013 RCT

Hyperbaric oxygen induces late neuroplasticity in post stroke patients--randomized, prospective trial.

Efrati S, Fishlev G, Bechor Y, et al.

J Neurotrauma | 2018 Systematic Review

Hyperbaric oxygen therapy in the treatment of acute severe traumatic brain injury: a systematic review

Daly S, Thorpe M, Rockswold S, et al.

J Neurotrauma | 2012 Pilot Study

A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and PTSD

Harch PG, Andrews SR, Fogarty EF, et al.

Scientific Reports | 2022 RCT

Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial.

Hadanny A, Zilberman-Itskovich S, Catalogna M, et al.

PLoS ONE | 2013 RCT

Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury — randomized prospective trial

Boussi-Gross R, Golan H, Fishlev G, et al.

See all Neurological research

View on PubMed Back to Research Library

Discuss with a qualified healthcare professional. Then: Review Coverage Guide View Recognised Conditions

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology