Meta-Analysis Psychopharmacology 2018

The treatment of cognitive dysfunction in dementia: a multiple treatments meta-analysis.

Perng CH, Chang YC, Tzang RF — Psychopharmacology, 2018

View Original on PubMed PMID 29502274

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

This meta-analysis evaluated factors influencing the efficacy of various pharmacotherapy and psychosocial treatments for cognitive dysfunction in dementia by synthesizing data from 235 studies.

What They Found

The study, involving 44,854 patients, found a positive overall treatment effect on cognitive dysfunction, with a pooled standardised mean difference of 0.439 (95% CI 0.374, 0.504). Meta-regression revealed higher efficacy in young patients and those with vascular dementia, particularly with specific symptomatic treatments.

Canadian Relevance

As indicated by the study metadata, this research has no direct Canadian connection.

Study Limitations

A limitation of this meta-analysis is the potential for heterogeneity among the included studies and publication bias, which were not fully detailed in the abstract.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Meta-Analysis
Category	Neurological
Source	Pubmed
PubMed ID	29502274
Year Published	2018
Journal	Psychopharmacology
MeSH Terms	Alzheimer Disease; Clinical Trials as Topic; Cognitive Dysfunction; Combined Modality Therapy; Complementary Therapies; Dementia; Donepezil; Ginkgo biloba; Humans; Plant Extracts; Treatment Outcome; Vinca Alkaloids; Ginkgo Extract

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Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology