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Case Report BMJ Case Rep 2025 Canadian

Two cases of highly concentrated hydrogen peroxide poisoning with portal venous gas treated using hyperbaric oxygen therapy

Vallélian M, Juillerat A, Sunic M, Schneider C, Boet S — BMJ Case Rep, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Canadian emergency physicians at the University of Ottawa reported on two patients who accidentally swallowed concentrated hydrogen peroxide, developed gas bubbles in the portal vein (the main vein to the liver), and were both treated with HBOT.

What They Found

Both patients, one with significant symptoms and one with none, had portal venous gas confirmed by CT scan. After HBOT, follow-up CT scans in both cases showed complete resolution of the gas. One patient had serious symptoms while the other was asymptomatic, but both responded to HBOT. The authors suggest HBOT should be considered for all cases of concentrated hydrogen peroxide ingestion causing gas embolism, regardless of symptom severity.

What This Means for Canadian Patients

Concentrated hydrogen peroxide products are available as alternative health products in Canada, and accidental ingestion, particularly in children, is a real risk. This Canadian case report demonstrates that HBOT is effective even in patients without severe symptoms, which may prevent complications from developing. Canadian emergency physicians and poison control centres should consider HBOT early in these cases.

Canadian Relevance

This is a Canadian study (University of Ottawa). Arterial and venous gas embolism are OHIP-covered indications for HBOT in Ontario, and this report directly supports that coverage for hydrogen peroxide poisoning cases.

Study Limitations

With only two cases, it is not possible to establish definitive treatment guidelines; the threshold for HBOT versus observation alone in asymptomatic patients with portal venous gas remains unclear.

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Study Details

Study Type Case Report
Category Decompression Sickness
Source Pubmed
PubMed ID 39922573
Year Published 2025
Journal BMJ Case Rep
MeSH Terms Humans; Hyperbaric Oxygenation; Hydrogen Peroxide; Portal Vein; Male; Embolism, Air; Tomography, X-Ray Computed; Adult; Female; Middle Aged; Treatment Outcome

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.